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KMID : 0043319900130040379
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Archives of Pharmacal Research
1990 Volume.13 No. 4 p.379 ~ p.381
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Effect of Calcium on Estrogen and Follicle Stimulating Hormaone Secretion in Rabbits
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Rabia AM
El Shishtawy MM/Ibrahim TM/El Gayar AM
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Abstract
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The effect of calcium gluconate on estrogen (estradiol) serum level as well as follicle stimulating hormone level was studied. Our results revealed that oral administration of calcium gluconate (100mg/kg body weight) to adult non-pregnant female rabbits caused a significant increase of serum levels of estradiol and follicle stimulating hormone. On the other hand, oral contraceptive (Norminest tablets) decreased significantly follicle stimulating hormone serum level, while combined administration of calcium gluconate and oral contraceptive caused significant increase of serum level of follicle stimulating hormone compared with control values. Also, concurrent administration of calcium gluconate and Norminest tablet increased significantly the rate of conception compared with group received Norminest tablets only. These results indicated that combined administration of calcium and oral contraceptives must be cautiously.
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